Defy Medical

About Defy Medical

Defy Medical is one of the most established names in hormone therapy telehealth, operating since 2013 — giving it over a decade of clinical experience that most GLP-1 startups cannot match. The company built its reputation in testosterone replacement therapy (TRT) and has expanded into GLP-1 weight management with an unusually broad medication menu: semaglutide, liraglutide, and oral semaglutide, available in both brand-name and compounded formulations. Monthly pricing ranges from $199-$399, placing Defy in the mid-to-upper tier of the market.

Patient satisfaction data is outstanding. Defy holds a 4.9 rating on Trustpilot across 3,775+ reviews, one of the highest scores we have encountered in our coverage of telehealth providers. The near-perfect rating at meaningful volume suggests a genuinely superior patient experience. The company does carry a C rating with the BBB, which typically reflects complaint resolution timelines rather than complaint severity — a pattern common among smaller medical practices that prioritize clinical care over administrative response workflows.

What distinguishes Defy Medical clinically is its deep expertise in hormone optimization. The provider team includes physicians who have spent years managing complex hormonal cases, and that expertise translates directly into more nuanced GLP-1 prescribing. Patients receive comprehensive lab testing, and treatment protocols account for thyroid function, testosterone levels, insulin sensitivity, and other metabolic markers that influence how effectively GLP-1 medications work. This is a high-support model with genuine clinical depth.

The inclusion of oral semaglutide as an option is a notable differentiator. Many telehealth providers offer only injectable formulations, which can be a barrier for needle-averse patients. Defy’s willingness to prescribe across multiple delivery methods — injectable semaglutide, injectable liraglutide, and oral semaglutide — means patients have more flexibility to find a protocol that fits their lifestyle and tolerance. The company also offers combination protocols for patients on concurrent TRT or thyroid therapy, an integration few competitors can provide.

Defy’s main drawback is cost accessibility. At $199-$399/month, the platform sits above budget-friendly competitors, and the depth of care — while excellent — may be more than a straightforward weight loss patient needs. Defy Medical is best suited for patients with complex metabolic or hormonal profiles who want a provider capable of managing multiple conditions simultaneously, not just prescribing a GLP-1 and checking in periodically.

Defy Medical GLP-1 Medications

At a Glance